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Comparisons · November 4, 2026 · 7 min read

Does Enfamil NeuroPro Have Palm Oil? Similac 360 Doesn't

Enfamil NeuroPro powder lists palm olein oil; Similac 360 Total Care powder lists safflower, soy and coconut oils. HMOs, lactose and per 5 fl oz numbers compared.

By Chris Carrillo · Reviewed by Armin Rad, Co-Founder & CTO, Aurascan · November 4, 2026

Every article is checked against primary sources before publication. How we review

Illustration of Two heaped measuring scoops of powder beside a glass baby bottle

Yes, Enfamil NeuroPro powder can contain palm oil: the vegetable oil line on the Enfamil product page lists palm olein oil among the oils it 'contains one or more of.' Similac 360 Total Care powder names high oleic safflower, soy and coconut oils and no palm olein, and it lists five named HMOs where NeuroPro lists one. Those two differences, in fat sources and HMO count, are the most visible ones on the labels. Their per-100-Calorie nutrient numbers are close, and both fall within the U.S. ranges for the nutrients those ranges cover. This article places the label facts side by side and leaves the choice to you.

Key takeaways:

  • Similac 360 Total Care's ingredient list names high oleic safflower oil, soy oil, and coconut oil, and does not list palm olein.
  • Enfamil NeuroPro's vegetable oil line may contain palm olein, but the label does not say which oils are in a given tub or in what share.
  • Similac lists five named HMOs. NeuroPro lists 2'-FL, which its page says is not from human milk, plus two prebiotics.
  • Both powders list nonfat milk and lactose as their first two ingredients.
  • Per 100 Calories, the two powders are close, and both fall within the cited federal ranges for the listed nutrients.

What Are the Key Label Differences Between Similac 360 and Enfamil NeuroPro Powder?

The main label differences are the fat blend, the HMO and prebiotic list, the MFGM footnote, and several vitamin and mineral amounts. Both are milk-based powders that begin with nonfat milk and lactose.

Similac 360 Total Care powder lists nonfat milk, lactose, high oleic safflower oil, whey protein concentrate, soy oil, coconut oil, and five HMOs, followed by a long list of minerals, vitamins, and nucleotides present at less than 2%. Its allergen statement on the Abbott product page reads 'Contains milk and soy ingredients.' Enfamil NeuroPro powder lists nonfat milk, lactose, a vegetable oil line, whey protein concentrate, and 2'-FL, with galactooligosaccharides (GOS) and polydextrose (PDX) as prebiotics. The remaining NeuroPro ingredients are not reproduced in this article, and the full ingredient list appears on the Enfamil product page.

A few differences are easy to miss when you scan a tub:

  • Fat source: Similac names each oil. NeuroPro names one vegetable oil line that 'contains one or more of the following' oils.
  • HMOs: Similac lists five. NeuroPro lists one HMO and two prebiotics, which are not HMOs.
  • MFGM: NeuroPro's page footnotes its whey protein concentrate as a source of MFGM components. The Similac ingredient list does not use MFGM wording.
  • Carrageenan: neither powder ingredient list includes carrageenan. The Similac ready-to-feed and Enfamil liquid ingredient lists on the same pages do include it.

Does Enfamil NeuroPro Have Palm Olein, and Does Similac 360 Total Care Contain It?

Yes, the NeuroPro label lists palm olein as one possible oil in its vegetable oil line, and Similac 360 Total Care's ingredient list does not include palm olein. Similac's fat sources are high oleic safflower oil, soy oil, and coconut oil. The NeuroPro line also lists coconut oil, soy oil, and high oleic sunflower oil, and the label does not state how much of each is in a tub.

The NeuroPro wording matters for interpretation. Because the line says 'contains one or more of the following,' the palm olein may be the only oil in that line or one of several, and the page does not say. Shoppers who want the exact oil profile of a specific tub will need the manufacturer's current label or a direct question to the manufacturer.

Do Similac 360 and Enfamil NeuroPro Both Contain Human Milk Oligosaccharides?

Yes. Similac 360 Total Care lists five HMOs, and Enfamil NeuroPro lists one HMO, 2'-fucosyllactose (2'-FL), along with two prebiotics.

Similac's HMOs are 2'-Fucosyllactose, Lacto-N-Tetraose, 3-Fucosyllactose, 6'-Sialyllactose, and 3'-Sialyllactose. Its label marks them with an asterisk meaning 'HMO, not from human milk.' NeuroPro's page describes its 2'-FL as 'Not from human milk.' GOS and PDX are listed as prebiotics, which are fibers that feed gut bacteria, and they are not HMOs.

Neither label discloses the milligram amount of any individual HMO per serving, so the labels alone cannot show how much HMO either powder delivers.

How Much Lactose Does Each Powder List, and Is It Disclosed?

No, neither label quoted here gives a lactose amount in grams per serving. Both powders list lactose as the second ingredient, after nonfat milk, and total carbohydrate is listed instead: 10.5 g per 100 Calories for Similac 360 Total Care and 11.3 g per 100 Calories for Enfamil NeuroPro.

Because total carbohydrate includes lactose and other carbohydrates, the two numbers cannot be used to calculate how much lactose either powder contains. Any change in formula for an infant with a milk-related or lactose-related condition should be guided by a clinician.

Do Enfamil NeuroPro and Similac 360 Total Care List MFGM on the Label?

Enfamil NeuroPro's page footnotes its whey protein concentrate as 'A source of MFGM (Milk Fat Globule Membrane Composed Of Proteins And Fats) Components.' The Similac 360 Total Care ingredient list quoted here does not use MFGM wording.

The NeuroPro footnote says the whey protein concentrate is a source of MFGM components, which is different from stating a specific MFGM amount. Neither label quoted here gives an MFGM milligram figure, so the footnote cannot be used to compare the two products' MFGM content.

What Are the Per-100-Calorie Numbers for Each Powder, and What Is Not Disclosed?

Per 100 Calories, which is 5 fl oz prepared as directed, Similac 360 Total Care powder lists 1000 mg linoleic acid and 24 mg sodium, while Enfamil NeuroPro powder lists 780 mg linoleic acid and 27 mg sodium. The table below places both sets of numbers beside the ranges in 21 CFR 107.100.

Nutrient (per 100 Calories)Similac 360 Total Care powderEnfamil NeuroPro powder21 CFR 107.100 requirement
Protein2.07 g2.1 g1.8 to 4.5 g
Fat5.6 g5.3 g3.3 to 6.0 g
Carbohydrate10.5 g11.3 gNot cited here
Linoleic acid1000 mg780 mgMinimum 300 mg
Vitamin D60 IU70 IU40 to 100 IU
Calcium78 mg78 mgMinimum 60 mg
Iron1.8 mg1.8 mg0.15 to 3.0 mg
Sodium24 mg27 mg20 to 60 mg
Choline24 mg24 mgNot cited here

Every listed value for both powders falls within the cited ranges where a range exists. The FDA's infant formula questions and answers says U.S. nutrient specifications 'include minimum amounts for 29 nutrients and maximum amounts for 9 of those nutrients.' The ranges cover only the nutrients named in the regulation, so a 'within range' result says nothing about the oils, HMOs, or MFGM discussed above.

Neither product page cited here states DHA or ARA amounts per serving, and the milligram amount of each HMO is not stated on either label. Price per ounce is not part of this comparison either. Because formulas are reformulated over time, confirm these figures against the current manufacturer label before buying.

How Do You Read Palm Olein, HMO, and MFGM Claims on an Infant Formula Label?

Read the ingredient list for named oils, count HMOs by name, and check footnotes for MFGM or prebiotic wording, since 'source of' language does not state an amount. Compare numbers only when the serving basis matches.

  • Find the fat line. A phrase like 'contains one or more of the following' means the exact oils may vary by tub.
  • Separate HMOs from prebiotics such as GOS and polydextrose on the list.
  • Read footnotes. 'A source of' describes a component, not a quantity.
  • Check the Nutrition Facts or per-100-Calorie table, and confirm the preparation method, such as 5 fl oz prepared as directed.
  • Read the allergen statement. Similac's states 'Contains milk and soy ingredients.' NeuroPro's allergen statement is not quoted here, so check the tub.
  • Check the intended age. NeuroPro's page describes the formula as 'only intended for 0-12 months.'
  • Compare the same product form. The Similac ready-to-feed and Enfamil liquid lists differ from the powders, including on carrageenan.

For another baby and toddler label comparison, see Is Once Upon a Farm Healthier Than Little Spoon? 7 g vs 9 g.

These label facts cannot show how any individual infant tolerates a formula. Questions about switching formulas, feeding plans, or conditions such as allergy or digestive concerns should go to a pediatrician.

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Common questions

Can I switch from Similac 360 to Enfamil NeuroPro?
Whether to switch is a question for your pediatrician, because the label differences in oil blend, HMO count, and prebiotics cannot show how a specific infant will respond. The NeuroPro page describes the formula as only intended for 0-12 months.
What is the Enfamil equivalent to Similac 360?
Neither brand page names an equivalent. Enfamil NeuroPro powder is the Enfamil formula compared here: per 100 Calories it lists 2.1 g protein and 5.3 g fat versus 2.07 g and 5.6 g for Similac 360 Total Care, and it lists one HMO instead of five.
Which is better for my baby, Enfamil or Similac?
The label facts do not establish that either powder is better for a given baby, and this article does not rank them. A pediatrician can consider feeding needs, tolerance, and medical history.
Does Enfamil NeuroPro have palm oil?
Yes, the NeuroPro powder ingredient list includes a vegetable oil line that may contain palm olein oil, but the label does not state how much of the blend is palm olein.
Does either powder contain carrageenan?
Neither powder ingredient list quoted here includes carrageenan, although the Similac ready-to-feed and Enfamil liquid ingredient lists on the same pages do.
Do Similac 360 and Enfamil NeuroPro both contain HMOs?
Yes. Similac 360 Total Care lists five named HMOs, and Enfamil NeuroPro lists one HMO, 2'-FL, which its page says is not from human milk.

Sources

  1. Similac 360 Total Care (abbottnutrition.com)
  2. Enfamil NeuroPro Infant Formula, Powder Tub 20.7 oz (enfamil.com)
  3. Questions and Answers Concerning Infant Formula (fda.gov)
  4. 21 CFR 107.100 Nutrient specifications (ecfr.gov)

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